BP404T – PHARMACOLOGY – I THEORY

Categories: Bachelor of Pharmacy
Wishlist Share

About Course

Scope:

The main purpose of the subject is to understand what drugs do to the living organisms and how their effects can be applied to therapeutics. The subject covers the information about the drugs like, mechanism of action, physiological and biochemical effects (pharmacodynamics) as well as absorption, distribution, metabolism and excretion (pharmacokinetics) along with the adverse effects, clinical uses, interactions, doses, contraindications and routes of administration of different classes of drugs.

Objectives:

Upon completion of this course the student should be able to
1. Understand the pharmacological actions of different categories of drugs
2. Explain the mechanism of drug action at organ system/sub cellular/ macromolecular levels.
3. Apply the basic pharmacological knowledge in the prevention and treatment of various diseases.
4. Observe the effect of drugs on animals by simulated experiments
5. Appreciate correlation of pharmacology with other bio medical sciences

Show More

Course Content

UNIT I – General Pharmacology
a. Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy. b. Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination

  • Introduction to Pharmacology
  • Nature and Source of Drugs
  • Routes of Drug Administration and Essential Drugs Concept
  • Agonists, Antagonists, and Spare Receptors
  • Addiction, Tolerance, Dependence, Tachyphylaxis, Idiosyncrasy, and Allergy
  • Membrane Transport in Pharmacology and Physiology
  • Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs
  • Enzyme Induction, Enzyme Inhibition, and Kinetics of Elimination
  • Drug Discovery and Clinical Evaluation of New Drugs
  • Pharmacodynamics – Principles and Mechanisms of Drug Action
  • Receptor Theories and Classification of Receptors, Regulation of Receptors
  • Drug-Receptor Interactions and Signal Transduction Mechanisms
  • Dose-Response Relationship
  • Therapeutic Index (TI)

UNIT II – General Pharmacology
a. Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action. b. Adverse drug reactions. c. Drug interactions (pharmacokinetic and pharmacodynamic) d. Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.

UNIT III – Pharmacology of drugs acting on peripheral nervous system
a. Organization and function of ANS. b.Neurohumoral transmission,co-transmission and classification of neurotransmitters. c. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics. d. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral). e. Local anesthetic agents. f. Drugs used in myasthenia gravis and glaucoma

UNIT IV – Pharmacology of drugs acting on central nervous system
a. Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine. b. General anesthetics and pre-anesthetics. c. Sedatives, hypnotics and centrally acting muscle relaxants. d. Anti-epileptics e. Alcohols and disulfiram

UNIT V – Pharmacology of drugs acting on central nervous system
a. Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents, anti-manics and hallucinogens. b. Drugs used in Parkinsons disease and Alzheimer’s disease. c. CNS stimulants and nootropics. d. Opioid analgesics and antagonists e. Drug addiction, drug abuse, tolerance and dependence.

Inpharmedia | Online Platform for Pharmacy Education

Ultimate Learning Platform for Pharmacy

+91 99804454335
fosterprepbuddy@gmail.com
error: Content is protected !!